Since murder—in a detective story—requires a motive, money is a very frequent one, as is revenge. Since confusion as to motive helps a detective story to be interesting, Comingling the possible motives of money and revenge can make for a story being very interesting.
In golden age mysteries, this often took the form of a relative who went off and made his fortune in Africa, or in Australia, or in America. To England in the early 1900s, there were a large number of far-off places in which it was possible to make a fortune and to make deadly enemies while one was doing it. This, rather usefully, made for a ready supply of fictional millionaires with dubious pasts in detective fiction. A story might go any way of it, with the millionaire being killed for his money, or for how he got his money, and this, in turn, made any detective story which featured a millionaire who made his fortune in foreign lands instantly inscrutable. There were many ways the story could go until sufficient facts were put into place to know which way it had gone.
I am not sure that this sort of plot is really open to contemporary stories any more. For one thing, there is noplace where popular imagination will accept that fortunes are easily made (if you don’t contract a deadly disease, etc). The closest I think one can come would be a tech startup of some kind. The problem is that tech startups happen within the bosom of civilization. Worse, they are started by the most harmless people that one can imagine: nerds. Popular imagination may accept someone making a fortune in a tech startup, but will not accept the nerd who made this fortune having murdered someone in order to keep it to himself.
It would actually be somewhat plausible to have a more daring person use the small amount of money he had from his parents to fund a startup with a nerd friend and then to get rich from it, so we need not be strictly limited to having a nerd as our rich man. The problem is that it would still be the nerd who would have to get revenge, and this would not be very plausible. At the outskirts, the nerd might somehow have acquired a wife and children—though I think this would tend to strain the credulity of the average reader (more because the nerd is conceived of like a sorcerer, and sorcerers must be virgins to be powerful)—and one of the children of the nerd might grow up to seek vengeance for his father. That said, I don’t think that anyone will really buy it.
I do think it could be made to work if you want to go the dark route, though. You can have the millionaire who cheated the nerd also have cuckolded him, so that the child who kills him is actually his own offspring, having inherited his daring and risk-taking from his biological father. It would make for one heck of a reveal at the end, but I don’t like to go the dark route, myself.
To some degree the problem is that the world has become over-technologized for there to be anyone to kill in order to keep a fortune to oneself. Precious metals, oil, etc.—all these are now located by experts using expensive machines, and cannot be extracted without the sort of precise data provided by these experts. The other thing is that technology is a magnifier. Where it does provide wealth, it provides it in such abundance that it is no great hardship to share. The diamond mines, or oil wells, or whatever the millionaire made his millions on in the early 1900s provided enough wealth for one man, but would have provided only prosperity for two. Diamond mines might very plausibly produce a few hundred diamonds; a gold mine might very plausibly produce only a few hundred pounds of gold. That would be wonderful in one year; it’s not actually that much to buy a mansion on and keep servants for another forty years.
The other problem is that the modern ways of making a fortune, though they take a lot of work, involve very little suffering. No one digs all day under a scorching sun to develop a cell phone app. No one gets an almost deadly fever, or is bitten by venomous insects, or is mauled by a jaguar, while creating a website that takes pictures of your cat and gives you wine suggestions. In short, modern fortunes are not made in a romantic way. Something as dramatic as a deadly vengeance simply doesn’t go with the utterly prosaic ways in which modern fortunes are made.
I have faith that the basic outline of the plot can be made to work, but I think it will take a great deal of work, indeed, to come up with the way to do it.